September 17, 2026

@michaelokun

What resonated with me most from this morning’s DBS Think Tank session on sEEG-guided neuromodulation was the sense that we are moving beyond simply asking where to stimulate and toward understanding the circuits, signals and physiology that can tell us how to stimulate better. Sameer Sheth from Baylor showed how sEEG can become a powerful tool for mapping human brain networks and using what we learn to build better and more personalized DBS approaches. Jonathan Parker from Mayo Clinic highlighted the remarkable information embedded in evoked potentials and how probing circuit responses may help us understand connectivity and ultimately guide neuromodulation. Prasad Shirvalkar from UCSF brought this beautifully into the world of chronic pain, demonstrating how intracranial recordings can reveal individualized pain biomarkers and potentially open the door to closed-loop therapies. Three different perspectives, but one powerful message: the future of neuromodulation may depend less on treating a spot in the brain and more on listening to, understanding and intelligently modulating the network.