Device that assesses brain activity may help diagnose Parkinson’s

Delphi-MD, a system developed by Quantalx Neuroscience, may help diagnose Parkinson’s disease early and distinguish between its subtypes, especially those with rapid progression, according to recent research. This technology captures real-time brain activity, identifying subtle changes in neural networks even in the disease's early stages. By pinpointing patients with fast-progressing Parkinson’s, Delphi-MD may support earlier, more personalized treatment. Mark Hallett, MD, a scientific advisor for Quantalx, noted that Delphi-MD’s precision could transform Parkinson’s diagnosis and care by detecting minor brain network changes. The system uses noninvasive magnetic pulses to assess brain function, receiving U.S. breakthrough designation for use in diagnosing serious neurological conditions, like stroke and dementia. In the study, researchers compared neural responses to brain stimulation between 62 Parkinson’s patients and 76 healthy individuals, focusing on three brain areas: the motor cortex, dorsolateral prefrontal cortex, and visual cortex. Parkinson’s patients showed altered brain network responses, with unique patterns in the occipital lobe (visual cortex) helping to differentiate those with rapid progression. Subgroup analysis revealed that patients with rapid progression had distinct neural patterns in response to visual cortex stimulation, allowing researchers to distinguish these patients with 85% accuracy. This specific neural response in the visual cortex was linked to more advanced disease stages, underscoring its potential for early detection of aggressive Parkinson’s cases.