Key takeaways from the 2026 Van Andel Institute Parkinson's symposium

Researchers and people living with Parkinson's gathered in Michigan for the annual Van Andel Institute symposium to focus on a clear goal: turning discoveries about cellular mechanics into real treatments that can slow the condition. The main target is alpha-synuclein, a protein that misfolds and clumps into sticky clusters called Lewy bodies. These clusters act like seeds, spreading through the brain and disrupting energy production in nerve cells. Understanding how these shapes form helps scientists figure out how to stop the spread. Another major focus is why certain brain cells are more fragile than others. Scientists found that rogue protein clumps can push the brain's immune cells into overdrive, releasing inflammatory chemicals that damage nearby neurons. Knowing this helps researchers design ways to protect these vulnerable cells. Finally, experts highlighted the growing importance of biomarkers, which are biological signposts like specific proteins or genes such as LRRK2 and GBA1. Tracking these markers gives doctors dashboard warning lights to spot changes early, measure how well treatments work, and tailor care to individual biology.