DBS-Plus May be a Safe and Feasible Approach to Slowing Parkinson’s Progression

A Phase 1 clinical study found that inserting a small piece of nerve tissue from a patient’s ankle into the brain during deep brain stimulation (DBS) surgery is a safe and feasible approach to supporting damaged dopaminergic neurons in Parkinson’s disease. This technique, called DBS-Plus, aims to slow symptom progression by promoting neuron survival. The study followed 18 patients (average age 62) undergoing DBS surgery, with nerve tissue implanted into one side of the brain. Over two years, MRI scans showed no abnormal growths or infections. The most common side effect was temporary loss of sensation in the foot or ankle. Cognitive assessments revealed only minor, expected changes, and motor symptoms improved significantly, with no decline over time. Researchers concluded that DBS-Plus met safety and feasibility goals, encouraging further clinical trials.