Apomorphine oral spray safe, efficient in Parkinson’s, study finds

Researchers are exploring a new, easier way to administer apomorphine, a drug used to manage sudden OFF episodes in Parkinson's disease. Typically, this drug is given by injection, but a new oromucosal solution (a liquid applied inside the mouth) could offer a less invasive option. The study involved two parts with a total of 25 patients. Patients received various doses of the oromucosal solution, subcutaneous injections, and sublingual film to compare their effects. The oromucosal solution was generally well-tolerated with typical side effects like low blood pressure, yawning, and fatigue. The drug levels in the blood increased with higher doses but not in a completely proportional way. Effectiveness: The highest dose of the oromucosal solution reached drug levels in the blood similar to those achieved with a 2 mg injection. It provided about half the drug levels seen with a 30 mg sublingual film. Clinical Relevance: This new method could offer a safe and efficient alternative for patients, making it easier to take the medication without the need for injections. This study shows promising results for a more user-friendly way to manage Parkinson's disease symptoms.