Higher-than-expected rate of gene mutations seen in Parkinson's patients

Researchers recommend offering genetic testing to all Parkinson’s disease patients due to a higher-than-expected rate of gene mutations found in these individuals, according to a study in the journal Brain. The study, which analyzed over 8,000 patients from various backgrounds, revealed that 13% had a genetic form of Parkinson’s. This rate was higher (18%) in patients with known risk factors like early onset, family history, or specific ancestry. Even among those without known risk factors, over 9% had genetic mutations. With new gene-specific treatments emerging, genetic testing could influence treatment plans and better inform patients about their prognosis and familial risks. Despite previous beliefs that only 5-10% of cases were genetic, limited access to genetic testing has been due to neurologists' unfamiliarity with genetics and limited availability of genetic counselors. However, advances in gene-specific treatments are changing this, and researchers suggest offering genetic testing to all Parkinson’s patients. Those interested can join the PDGENE study for free testing at the provided link.